Download Citation on ResearchGate | Antibacterial activity of Peganum harmala | Successive petroleum ether, chloroform and methanol extracts of Peganum. Successive petroleum ether, chloroform and methanol extracts of Peganum harmala seeds were tested (in vitro) for their antibacterial activity. examine the antibacterial activities of Peganum harmala extracts on the Key words: Antimicrobial effect, Biofilm, Peganum harmala, Pathogenic bacteria.

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Ehsanpour AA, Saadat E. Open in a separate window. The most important alkaloids in P. This article has been cited by other articles in PMC. Anti-listerial activity of ethanolic extracts of medicinal plants, Eremophila alternifolia and Eremophila duttonii, in food homogenates and milk.

Different parts antibacerial P. This study aimed to investigate the antimicrobial natibacterial of ethanol extract of P. MIC of extract on S. Meanwhile, the seed and root extract in combination with carbenicillin showed a relatively weak synergistic activity against MRSA. Dental caries is one the most prevalent diseases that affects humans throughout their lives.

Based on the obtained results, the root extract has a better antibacterial activity against Gram positive bacteria except L. The first tube in the above series without sign of visible growth was considered as the MIC.


In general, antibacterial activity of these two extracts was not considerably affected after temperature and pH treatment. Further antimicrobial and cytotoxicity studies on animals or human subjects are needed to obtain more accurate and applicable results. Study of the synergistic effect To determine the synergistic effect of the most effective parts of P.

Increasing the antibacterial activity of the different parts of P.

Mechanisms of antimicrobial resistance in bacteria. TLC Thin Layer Chromatography results revealed that seed and root extracts were different in terms of nature and content of their constituents.

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Harmal J Pharmaceut Sci. Gram negative bacterial species were Pseudomonas aeruginosa, Brucella melitensisProteus mirabilisSalmonella typhiEscherichia coli and Klebsiella pneumoniae. Thus, considering antibacterial activity of the seed and root extracts of P. Also, the seed and root extracts showed synergism in combination with novobiocin, colistin and carbenicillin.

Acute toxicological studies on the extract of Iraqi Peganum harmala in rats. Antimicrobial properties of Teucrium polium against some clinical pathogens.

These species were originally isolated from clinical specimens and identified by standard biochemical reactions based on morphological and biochemical characters according to the methods described in Bergey’s manual for systematic bacteriology Garrity et al. Afr J Pharm Pharmacol.


Antimicrobial Activity of Peganum Harmala L. on Streptococcus mutans Compared to % Chlorhexidine

antibacterisl Moreover, MIC values for seed and root extracts against B. Conclusion Despite the remarkable antimicrobial effects of high concentrations of P.

Also, all of the tested bacteria were resistant to colistin. Eur J Scientific Res. The turbidimetry of the suspension was adjusted to the McFarland 0. Microbial and viral drug resistance mechanisms. Please review our privacy policy.

Oral colonization by Streptococcus mutans and caries development is reduced upon deletion of carbonic anhydrase VI expression in saliva. Acknowledgements The authors wish to thank the vice chancellor for research of Shahid Chamran University, Ahvaz, Iran, for the research grant and financial support.

Efficient harmapa vitro multiplication of Syrian Rue Peganum harmala L. Tested against Gram negative bacteria the obtained results were inconsistent.