Nasopharyngeal angiofibroma is a histologically benign but locally aggressive vascular tumor that grows in the back of the nasal cavity. It most commonly affects adolescent males and may grow into fissures of the. Nasoangiofibroma youth is a highly vascularized tumor almost exclusively male adolescents presentation. % represents % of head and. Angiofibroma nasofaring juvenile – Free download as PDF File .pdf), Text File . txt) or read online for free.

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Bilateral vascular supply in juvenile nasopharyngeal angiofibromas. Sagittal section in computed tomography scans showing site and extent of the lesion. Please review our privacy policy.

JNA is classified as Type I when the tumor is restricted to the nasal cavity and the nasopharynx without bone destruction, Type II when the tumor invades the pterygomaxillary fossa and maxillary, sphenoidal and ethmoid naofaring with bone destruction, Type III when the tumor invades the infratemporal fossa, the orbit, and the parasellar region but remains lateral to the cavernous sinus and Type IV when the tumor invades the cavernous sinus, the optic chiasma and the pituitary fossa.

Extended osteoplastic maxillotomy for total excision of giant multicompartmental juvenile nasopharyngeal angiofibroma. The main clinical presentation of JNA is unilateral nasal obstruction with or without epistaxis. Juvenile nasopharyngeal angiofibromas are benign but highly vascular tumours. Contrast enhanced MRIs are used to achieve avid enhancement with flow voids.

Histopathology reveals a fibrocellular stroma with spindle cells and haphazard arrangement of collagen interspersed with an irregular vascular pattern. The final diagnosis is achieved by histopathologic examination of tissue sections either on incisional or excisional biopsy. This tumor originates in the lateral wall of the nasal cavity, close to the superior border of the sphenopalatine foramen.


Clinical examination reveals a firm and friable mass in the nasopharynx and nose. Int J Pediatr Otorhinolaryngol. This article has been cited by other articles in PMC. Non-small-cell lung carcinoma Xngiofibroma carcinoma Adenocarcinoma Mucinous cystadenocarcinoma Large-cell lung carcinoma Rhabdoid carcinoma Sarcomatoid carcinoma Carcinoid Salivary gland—like carcinoma Adenosquamous carcinoma Papillary adenocarcinoma Giant-cell carcinoma.

Juvenile nasopharyngeal angiofibroma

Imaging in the diagnosis of juvenile nasopharyngeal angiofibroma. Abstract Juvenile nasopharyngeal angiofibroma JNA is a rare benign tumor arising predominantly in the nasopharynx of adolescent males.

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Articles from Journal of Oral and Maxillofacial Pathology: Adolescents and young adults between 14 and 25 years are affected, and there is a distinct male predominance. This feature may be helpful is differentiating juvejile other more aggressive lesions. Pancoast tumor Solitary pulmonary nodule Central lung Peripheral lung Bronchial leiomyoma.

When diagnosed early the patients are treated with a combination of preoperative embolization and surgical resection providing a good prognosis. Histopathological examination revealed a proliferative connective tissue stroma interspersed with a thick vascular network. Strayer; Emanuel Rubin The origin and development of JNA is not fully understood.

New author database being installed, click here for details. Nasal cavity, paranasal sinuses, nasopharynx Other tumors Nasopharyngeal angiofibroma Author: Nasopharyngeal carcinoma Nasopharyngeal carcinoma. J Clin Imaging Sci.

Pathology Outlines – Nasopharyngeal angiofibroma

JNA is benign but locally destructive. Several reports suggest that JNA regresses over time. Imaging plays an important role in diagnosis, as biopsies should be avoided due to the risk of brisk hemorrhage, as well as staging. CT is particularly useful at delineating bony changes.

You can also scroll through stacks with your mouse wheel or the keyboard arrow keys. Modern imaging and its influence on the surgical treatment of juvenile angiofibroma. Histopathologically JNA shows a fibrocellular stroma with spindle cells and haphazardly arranged collagen interspersed with an irregular vascular pattern. Type III is a calabash-like massive tumor lobe in the middle cranial fossa. Edit article Share article View revision history. Accordingly, the treatment options, operative approach and nasfaring can be determined.


Preoperative embolisation of tumour may be of some use in reducing intraoperative bleeding. Advanced JNA is much more difficult to treat. Unable to process the angiofiboma. Arteriography followed by preoperative embolization and surgical resection is the treatment of choice.

Extensive bony destruction is usually not a feature, but rather bone is remodelled or resorbed. Case 6 Case 6. Markers of vascular differentiation, proliferation and tissue remodeling in juvenile nasopharyngeal angiofibromas. Biopsy should be avoided as to avoid extensive bleeding since the tumor is composed of blood vessels without a muscular coat. A year-old male patient presented with a painless, progressive swelling in the upper jaw since 2 weeks.

Nasopharyngeal angiofibroma

Two types of lateral nasofaribg in juvenile nasopharyngeal angiofibroma: Medical treatment and radiation therapy are only of historical interest. Numerous mast cells were noted with a minimal inflammatory cell infiltrate. Angiofibromas originating outside the nasopharynx may appear as an intraoral mass in the retromolar or buccal space area.

The classification and clinical staging is relatively easy and helps to plan treatment and determine prognosis. Nasal cavity Esthesioneuroblastoma Nasopharynx Nasopharyngeal carcinoma Nasodaring angiofibroma Larynx Laryngeal cancer Laryngeal papillomatosis.

They may be locally aggressive.